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Manhattan plot of altered log10 (P values) for all phecodes evaluating their prevalence for each SD telomere shortening. Highlighted are associations results with −log10 P values in between ten and 120.Cells with endless proliferative ability – notably stem cells and cancer cells – have to activate a telomere lengthening system. There are two
All participants gave published knowledgeable consent for genotyping and facts linkage to medical reports. For definition of outcomes and covariates, see eTable one in the Complement.Why is telomerase "switched off" in the majority of cells? If telomeres shorten with Every replication of DNA, and telomeres protect the ends of DNA from damage, then
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